Scientists at Harvard University (USA) found that resveratrol, contained in red wine, prevents muscle loss in rats that lived under the reduced gravity characteristic of Mars. This substance will help to cope with the adverse effects of microgravity on the colonists. This was reported in a press release on Phys.org.
To simulate the attraction on Mars, rodents were suspended from the ceiling of the cage using a leash covering the entire body. 24 male rats were either subjected to normal stress (terrestrial conditions) or reduced to 40 percent within 14 days. In each group, one half of the animals received resveratrol (150 milligrams per kilogram of body weight per day), and the other received only water.
Researchers weekly measured the circumference of the lower leg, as well as the grip strength of the front and hind limbs, and after 14 days evaluated the strength of the lower leg muscles. It turned out that the Martian conditions of gravity weakened the functions of muscles, reduced their weight and fiber content. However, the addition of resveratrol to food kept the condition of the front and hind legs at the level of rodents in the “earth” group.
At the same time, the protection was not complete: the supplement did not fully compensate for the loss of the average cross-sectional area of the plantar and calf muscle fibers. The positive effect itself is due to increased sensitivity to insulin and better absorption of glucose. This is true for astronauts who develop insulin resistance under microgravity conditions.
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